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Abstract #3790

Sex-dependent Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment

Zhengshi Yang1,2, Jessica Z.K. Caldwell1, Jeffrey L Cummings2, Aaron Ritter1, Jefferson W Kinney2, and Dietmar Cordes1,2,3
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Nevada Las Vegas, Las Vegas, NV, United States, 3University of Colorado, Boulder, CO, United States


Resting-state fMRI was used to investigate the aging effect on caudate function in mild cognitively impaired participants, with the focus of sex-dependent effect. Graph theory analysis was conducted to derive caudate nodal strength, which was then input to linear mixed effect model to evaluate its association with age. A striking aging effect was observed only in women with MCI but not in men with MCI, which was closely related to cognitive decline in woman participants. This finding suggests that caudate may be critical for alleviating cognitive decline in women with MCI.

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