Multiexponential T1ρ spectroscopy in liver fibrosis: A prospective animal experiment at 11.7T MRI
Junqi Xu1, Qianfeng Wang1, Xuchen Yu1, Jiawei Han1,2, Yimei Lu3, and He Wang1,2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, ShangHai, China, 2Human Phenome Institute, Fudan University, ShangHai, China, 3Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University, ShangHai, China
This study proposed a new method to assess the stage of liver fibrosis by signal curves clustering and multiexponential decay T1ρ spectral analysis. Compared to single component in normal tissue, liver fibrosis tissue has two T1ρ components, in carbon tetrachloride (CCI4) rat model. Meanwhile, T1ρ tends to increase with fibrosis score. Due to the spatial distribution of clusters reveal the fibrosis region, this method might contribute to diagnosis and staging of liver fibrosis.
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