This study assessed the impact of normalization scale and intensity discretization on first order radiomics features. Features were extracted from T2W images by varying the normalization parameter and bin width parameter of Pyradiomics library; Un-normalized (Without_normalization), normalized to scale1, normalized to scale 100 while keeping the bin width constant; and Bin width set to 20, bin width set to 40, bin width set to 60 while keeping the normalization scale set to 1. We found that the radiomics features were highly dependent on normalization scale and independent of bin width parameter.
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