Genetic Parkinson’s Disease (gPD) displays distinct clinical, demographic and pathological features from idiopathic Parkinson’s Disease (PD). The present study aims to search for alterations in the basal ganglia network (BGN) including substantia nigra (SN) and Subthalamic nucleus (STN) in a peculiar group of gPD using resting state (RS) fMRI. Genetic PD patients revealed less activation in the basal ganglia, SN+STN pathway and reduced connectivity with ACC, MCC and insula, which may reflect frontal lobe and autonomic dysfunction in these patients.
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