Basal Ganglia Connectivity as Assessed by Resting-State fMRI in Genetic Parkinson’s Disease
hacer dasgin1, basak soydas2, Gul Yalcin Cakmakli3, Bilge Volkan Salanci2, Eser Lay Ergun2, Bulent Elibol3, and Kader K. Oguz4
1Aysel Sabuncu Brain Research Center-UMRAM, Ankara, Turkey, 2Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey, 3Department of Neurology, Hacettepe University, Ankara, Turkey, 4Department of Radiology, Hacettepe University, Ankara, Turkey
Genetic Parkinson’s Disease (gPD) displays distinct clinical, demographic and pathological features from idiopathic Parkinson’s Disease (PD). The present study aims to search for alterations in the basal ganglia network (BGN) including substantia nigra (SN) and Subthalamic nucleus (STN) in a peculiar group of gPD using resting state (RS) fMRI. Genetic PD patients revealed less activation in the basal ganglia, SN+STN pathway and reduced connectivity with ACC, MCC and insula, which may reflect frontal lobe and autonomic dysfunction in these patients.
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