Abstract #3797

Basal Ganglia Connectivity as Assessed by Resting-State fMRI in Genetic Parkinson’s Disease

hacer dasgin¹, basak soydas², Gul Yalcin Cakmakli³, Bilge Volkan Salanci², Eser Lay Ergun², Bulent Elibol³, and Kader K. Oguz⁴

¹Aysel Sabuncu Brain Research Center-UMRAM, Ankara, Turkey, ²Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey, ³Department of Neurology, Hacettepe University, Ankara, Turkey, ⁴Department of Radiology, Hacettepe University, Ankara, Turkey

Synopsis

Genetic Parkinson’s Disease (gPD) displays distinct clinical, demographic and pathological features from idiopathic Parkinson’s Disease (PD). The present study aims to search for alterations in the basal ganglia network (BGN) including substantia nigra (SN) and Subthalamic nucleus (STN) in a peculiar group of gPD using resting state (RS) fMRI. Genetic PD patients revealed less activation in the basal ganglia, SN+STN pathway and reduced connectivity with ACC, MCC and insula, which may reflect frontal lobe and autonomic dysfunction in these patients.

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