Meeting Banner
Abstract #3824

Whole-Brain 3D CMRO2 Mapping with Prior-Guided Quantitative BOLD

Hyunyeol Lee1,2 and Felix Wehrli2
1Electronics Engineering, Kyungpook National University, Daegu, Korea, Republic of, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States


qBOLD permits noninvasive measurements of the two critical determinants of the BOLD signal, i.e., deoxygenated-blood-volume (DBV) and venous-oxygen-saturation-level (Yv), and along with CBF imaging, the cerebral metabolic rate of oxygen (CMRO2). Two major challenges in qBOLD are 1) separation of heme-originated R2′ from other signal sources, and 2) subsequent extraction of DBV and Yv. We had previously addressed these issues by developing a prior-guided qBOLD method. Here, we aimed to evaluate the method's utility in 3D CMRO2 mapping. Results suggest feasibility of the new qBOLD method as a practical means for measuring neurometabolic parameters over an extended brain coverage.

This abstract and the presentation materials are available to members only; a login is required.

Join Here