Abstract #3825

Optimized Ultrashort Echo Time – Magnetic Resonance Fingerprinting (UTE-MRF) for Myelin-Proton fraction Imaging

Zihan Zhou¹, Qing Li², Congyu Liao^3,4, Xiaozhi Cao^3,4, Huihui Ye⁵, Jianhui Zhong^1,6, and Hongjian He¹

¹Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, ²MR Collaborations, Siemens Healthineers Ltd, Shanghai, China, ³Department of Radiology, Stanford University, Stanford, CA, United States, ⁴Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ⁵State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, ⁶Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Synopsis

Optimization of MRF (MR fingerprinting) sequence is important for encoding MR tissue parameters with the maximal SNR for better quantification of representative tissues of WM, GM and CSF. Here, we targeted ultrashort T2 tissues and proposed an optimized acquisition parameter patterns for 3D ultrashort echo time MRF sequence with the goal of achieving higher quantification accuracy for myelin-proton based on Cramér‐Rao Lower Bound. Our results show that the optimized UTE-MRF sequence achieved high accuracy in myelin-proton quantification and whole-brain myelin-proton imaging in 15 min with 1mm isotropic resolution. The optimization also opens the door to further reduce scan time.

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