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Abstract #3825

Optimized Ultrashort Echo Time – Magnetic Resonance Fingerprinting (UTE-MRF) for Myelin-Proton fraction Imaging

Zihan Zhou1, Qing Li2, Congyu Liao3,4, Xiaozhi Cao3,4, Huihui Ye5, Jianhui Zhong1,6, and Hongjian He1
1Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2MR Collaborations, Siemens Healthineers Ltd, Shanghai, China, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 5State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, 6Department of Imaging Sciences, University of Rochester, Rochester, NY, United States


Optimization of MRF (MR fingerprinting) sequence is important for encoding MR tissue parameters with the maximal SNR for better quantification of representative tissues of WM, GM and CSF. Here, we targeted ultrashort T2 tissues and proposed an optimized acquisition parameter patterns for 3D ultrashort echo time MRF sequence with the goal of achieving higher quantification accuracy for myelin-proton based on Cramér‐Rao Lower Bound. Our results show that the optimized UTE-MRF sequence achieved high accuracy in myelin-proton quantification and whole-brain myelin-proton imaging in 15 min with 1mm isotropic resolution. The optimization also opens the door to further reduce scan time.

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