We proposed a Rapid Acquisition using Water pre-saturation for quantitative CEST imaging (RAW-qCEST) sequence, which validated by phantom experiments at 3-Tesla. Raw-qCEST allowed rapid acquisition of multiple readouts with varied saturation powers within one TR, by adding a water pre-saturation module that suppress interference among readouts and a seconds-long CEST saturation module before each readout. Simulation and phantom experiments showed that RAW-qCEST could accurately determine pH-related exchange rates, calculated using a modified omega-plot analysis. Owing to its fast speed and quantitative capability, RAW-qCEST could be useful for imaging stroke and cancers, which will be investigated in future.
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