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Abstract #3831

Rapid Acquisition using Water pre-saturation for quantitive CEST imaging (RAW-qCEST): exchange rate quantitation at 3-Tesla

Wenxuan Chen1, Lele Ma2, Zhensen Chen3, and Xiaolei Song1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China, 3Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China


We proposed a Rapid Acquisition using Water pre-saturation for quantitative CEST imaging (RAW-qCEST) sequence, which validated by phantom experiments at 3-Tesla. Raw-qCEST allowed rapid acquisition of multiple readouts with varied saturation powers within one TR, by adding a water pre-saturation module that suppress interference among readouts and a seconds-long CEST saturation module before each readout. Simulation and phantom experiments showed that RAW-qCEST could accurately determine pH-related exchange rates, calculated using a modified omega-plot analysis. Owing to its fast speed and quantitative capability, RAW-qCEST could be useful for imaging stroke and cancers, which will be investigated in future.

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