Abstract #3831

Rapid Acquisition using Water pre-saturation for quantitive CEST imaging (RAW-qCEST): exchange rate quantitation at 3-Tesla

Wenxuan Chen¹, Lele Ma², Zhensen Chen³, and Xiaolei Song¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China, ³Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

We proposed a Rapid Acquisition using Water pre-saturation for quantitative CEST imaging (RAW-qCEST) sequence, which validated by phantom experiments at 3-Tesla. Raw-qCEST allowed rapid acquisition of multiple readouts with varied saturation powers within one TR, by adding a water pre-saturation module that suppress interference among readouts and a seconds-long CEST saturation module before each readout. Simulation and phantom experiments showed that RAW-qCEST could accurately determine pH-related exchange rates, calculated using a modified omega-plot analysis. Owing to its fast speed and quantitative capability, RAW-qCEST could be useful for imaging stroke and cancers, which will be investigated in future.

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