Compressed sensing chemical exchange saturation transfer for simultaneous APT, ssMT, and rNOE imaging
Ying-Hua Chu1, Patrick Liebig2, Yifan Yuan3, He Wang4,5, and Yi-Cheng Hsu1
1Siemens Healthineers Ltd., Shanghai, China, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China, 4Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 5Human Phenome Institute, Fudan University, Shanghai, China
We proposed a fast 3D CEST imaging method using compressed sensing SPACE and demonstrated its routine clinical application for simultaneous APT, ssMT, and rNOE imaging. The total scan time of CEST images with 58 z-spectra and an off-resonance map was 6 minutes and 49 seconds. We used low refocusing flip angle and high bandwidth to achieve a narrow point spread function, and the images could be reproduced between different scans. This method could be used for tumor grading and treatment response assessment at 3T.
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