Abstract #3833

Compressed sensing chemical exchange saturation transfer for simultaneous APT, ssMT, and rNOE imaging

Ying-Hua Chu¹, Patrick Liebig², Yifan Yuan³, He Wang^4,5, and Yi-Cheng Hsu¹

¹Siemens Healthineers Ltd., Shanghai, China, ²Siemens Healthcare GmbH, Erlangen, Germany, ³Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China, ⁴Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ⁵Human Phenome Institute, Fudan University, Shanghai, China

Synopsis

We proposed a fast 3D CEST imaging method using compressed sensing SPACE and demonstrated its routine clinical application for simultaneous APT, ssMT, and rNOE imaging. The total scan time of CEST images with 58 z-spectra and an off-resonance map was 6 minutes and 49 seconds. We used low refocusing flip angle and high bandwidth to achieve a narrow point spread function, and the images could be reproduced between different scans. This method could be used for tumor grading and treatment response assessment at 3T.

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