Dynamic glucose enhanced MRI detects glucose-related responses in mouse brain under normoxia and hyperoxia
Jianpan Huang1, Zilin Chen1, Peter C. M. van Zijl2,3, Lok Hin Law1, Rohith Saai Pemmasani Prabakaran1,4, Se Weon Park1, Jiadi Xu2,3, and Kannie W. Y. Chan1
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China
Dynamic glucose enhanced (DGE) MRI can detect glucose-related events in the brain, however, the influence of oxygen levels on DGE signal remains unknown. Here, we investigated the DGE signal changes under normoxia and hyperoxia on mouse brain, using on-resonance variable delay multi-pulse (onVDMP) MRI. Significantly higher signal change under normoxia than that under hyperoxia was observed in parenchyma but not in cerebrospinal fluid (CSF). Without glucose infusion, a signal increment of about 3% was found in both parenchyma and CSF from hyperoxia to normoxia, interpreted as related to BOLD effect. These data provide insight into the origin of glucoCEST contrast.
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