Abstract #3837

Comparison of 3D amide proton transfer (APT) and four advanced diffusion models in gliomas IDH status decoding

Junjiao Hu¹, Huiting Zhang², Hu Guo³, Shan Jiang¹, Weijun Situ¹, Guang Yang⁴, and Jun Liu¹

¹Department of Radiology,The Second Xiangya Hospital, Central South University, Changsha, China, ²MR Scientific Marketing, Siemens Healthineers, Wuhan, China, ³MR Application, Siemens Healthineers, Changsha, China, ⁴Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science,East China Normal University, Shanghai, China

Synopsis

The purposed of study was to compare the diagnostic efficacy of APT imaging and four diffusion models, including DTI, DKI, NODDI, and MAP, in evaluating genotype IDH status, and to find the best imaging indicators for aiding accurate diagnoses and treatment decisions. Compared with IDH-mutant gliomas, IDH-wildtype gliomas had significantly higher mean and maximum of APTw, maximum axial, mean and radial diffusivity from DKI, maximum mean square diffusivity from MAP and maximum isotropic volume fraction from NODDI, as well as lower minimum APTw value.

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