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Abstract #3837

Comparison of 3D amide proton transfer (APT) and four advanced diffusion models in gliomas IDH status decoding

Junjiao Hu1, Huiting Zhang2, Hu Guo3, Shan Jiang1, Weijun Situ1, Guang Yang4, and Jun Liu1
1Department of Radiology,The Second Xiangya Hospital, Central South University, Changsha, China, 2MR Scientific Marketing, Siemens Healthineers, Wuhan, China, 3MR Application, Siemens Healthineers, Changsha, China, 4Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science,East China Normal University, Shanghai, China

Synopsis

The purposed of study was to compare the diagnostic efficacy of APT imaging and four diffusion models, including DTI, DKI, NODDI, and MAP, in evaluating genotype IDH status, and to find the best imaging indicators for aiding accurate diagnoses and treatment decisions. Compared with IDH-mutant gliomas, IDH-wildtype gliomas had significantly higher mean and maximum of APTw, maximum axial, mean and radial diffusivity from DKI, maximum mean square diffusivity from MAP and maximum isotropic volume fraction from NODDI, as well as lower minimum APTw value.

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