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Abstract #3838

Amide proton transfer weighted MRI in differentiating fat-poor angiomyolipoma from clearcell renal cell carcinoma

Qing Xu1, Weiqiang Dou2, and Jing Ye1
1Clinical Medical School of Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, China, 2GE Healthcare, MR Research, Beijing, China


This study aimed to explore the feasibility of amide proton transfer weighted (APTw) imaging in discriminating fat-poor angiomyolipoma (AML) from clear cell renal cell carcinoma (ccRCC). 19 ccRCC patients and 9 fat-poor AML patients were recruited for APTw imaging. ccRCC group showed significantly higher MTRasym compared to fat-poor AML group (P < 0.05). High AUC of 0.827 in ROC analysis validated the efficacy of APTw imaging in differentiating fat-poor AML from ccRCC. With these findings, APTw imaging may be considered an effective method providing added clinical value in differentiating fat-poor AML from ccRCC.

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