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Abstract #3839

Quantification of CMRO2 in Posterior Fossa Area Using Dynamic 17O-MRI

Hao Song1, Ali Caglar Özen1, Stefan Schumann2, and Michael Bock1
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2Dept. of Anesthesiology and Critical Care, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Synopsis

Direct quantification of cerebral metabolic rate of oxygen consumption (CMRO2) is possible with dynamic 17O-MRI after inhalation of isotope-enriched 17O2. In this work, we investigated oxygen metabolism in posterior fossa tissue including cerebellum, pons and midbrain. The determined CMRO2 values in these areas were in good agreement with literature values obtained by 15O-PET studies. Our results demonstrate that dynamic 17O-MRI may provide a valuable tool for direct measurement of CMRO2 in posterior fossa tissue.

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