Chemical exchange saturation transfer (CEST) imaging shows great potentials in the diagnosis of brain diseases. However, there are still many challenges in the hepatic disease due to the fat suppression and large B0 inhomogeneity. In this study, we achieved CEST imaging with simultaneous B0 correction in one sequence, and conducted a pixel-by-pixel prediction on the background reference Z-spectra representing the magnetization transfer and direct saturation effects. Our approach also effectively separated the amide proton transfer (APT) effects from the mixing effect of fat and nuclear Overhauser enhancement (NOE), by subtracting the background reference Z-spectra from the predicted Z-spectra.
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