Using 3D Amide Proton Transfer weighted imaging at 3T to investigate lesions and normal-appearing white matter in Multiple Sclerosis
Ibrahim Khormi1,2,3, Oun Al-iedani1,2, Bryan Paton2,4, Jeannette Lechner-Scott 2,5,6, Abdulaziz Alshehri1,2, Amir Fazlollahi7,8, Stefano Casagranda9, Christos Papageorgakis9, Margarita Arango-Lievano9, Anne-Louise Ponsonby10,11, Patrick Liebig12, and Saadallah Ramadan1,2
1School of Health Sciences, University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3College of Applied Medical Sciences, University of Jeddah, Jeddah, Saudi Arabia, 4School of Psychology, University of Newcastle, Newcastle, Australia, 5School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, 6Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia, 7CSIRO Health and Biosecurity, Brisbane, Australia, 8Queensland Brain Institute, The University of Queensland, Brisbane, Australia, 9Olea Medical, La Ciotat, France, 10The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 11Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia, 12Siemens Healthcare GmbH, Erlangen, Germany
This novel study explores amide proton transfer weighted (APTw) imaging in people with relapsing-remitting multiple sclerosis (pw-RRMS). We evaluated the APTw signal intensity in selected MS lesions and normal-appearing white matter (NAMW) regions in 9 pw-RRMS. Compared to NAWM regions, a statistically significant increase in APTw signal intensity was observed in the MS lesions. Elevated APTw signal intensity could mark increased mobile myelin proteins decomposition and accumulation from the demyelination process.
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