Abstract #3845

Using 3D Amide Proton Transfer weighted imaging at 3T to investigate lesions and normal-appearing white matter in Multiple Sclerosis

Ibrahim Khormi^1,2,3, Oun Al-iedani^1,2, Bryan Paton^2,4, Jeannette Lechner-Scott ^2,5,6, Abdulaziz Alshehri^1,2, Amir Fazlollahi^7,8, Stefano Casagranda⁹, Christos Papageorgakis⁹, Margarita Arango-Lievano⁹, Anne-Louise Ponsonby^10,11, Patrick Liebig¹², and Saadallah Ramadan^1,2

¹School of Health Sciences, University of Newcastle, Newcastle, Australia, ²Hunter Medical Research Institute, Newcastle, Australia, ³College of Applied Medical Sciences, University of Jeddah, Jeddah, Saudi Arabia, ⁴School of Psychology, University of Newcastle, Newcastle, Australia, ⁵School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, ⁶Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia, ⁷CSIRO Health and Biosecurity, Brisbane, Australia, ⁸Queensland Brain Institute, The University of Queensland, Brisbane, Australia, ⁹Olea Medical, La Ciotat, France, ¹⁰The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ¹¹Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Australia, ¹²Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

This novel study explores amide proton transfer weighted (APTw) imaging in people with relapsing-remitting multiple sclerosis (pw-RRMS). We evaluated the APTw signal intensity in selected MS lesions and normal-appearing white matter (NAMW) regions in 9 pw-RRMS. Compared to NAWM regions, a statistically significant increase in APTw signal intensity was observed in the MS lesions. Elevated APTw signal intensity could mark increased mobile myelin proteins decomposition and accumulation from the demyelination process.

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