Detecting dopamine in vivo is critical for understanding many neurologic and psychiatric disorders. In this work, we developed a paramagnetic CEST-MRI method for dopamine detection using NaHoF4@DBA nanoparticles. Our results showed that the dopamine in mouse brain can be selectively enriched in the surface of the nanoparticles and detected by CEST-MRI. Moreover, we found that the magnitude of ST% map reflecting dopamine levels in the brain of SZ mice was relatively higher than that of PD mice.
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