Detecting dopamine in vivo using paramagnetic CEST-MRI at 11.7T
Ying Liu1, Xianfu Meng2,3, and He Wang1,4
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China, 3Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Tongji University Cancer Center, Shanghai, China, 4Human Phenome Institute, Fudan University, Shanghai, China
Detecting dopamine in vivo is critical for understanding many neurologic and psychiatric disorders. In this work, we developed a paramagnetic CEST-MRI method for dopamine detection using NaHoF4@DBA nanoparticles. Our results showed that the dopamine in mouse brain can be selectively enriched in the surface of the nanoparticles and detected by CEST-MRI. Moreover, we found that the magnitude of ST% map reflecting dopamine levels in the brain of SZ mice was relatively higher than that of PD mice.
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