Abstract #3844

Detecting dopamine in vivo using paramagnetic CEST-MRI at 11.7T

Ying Liu¹, Xianfu Meng^2,3, and He Wang^1,4

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China, ³Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Tongji University Cancer Center, Shanghai, China, ⁴Human Phenome Institute, Fudan University, Shanghai, China

Synopsis

Detecting dopamine in vivo is critical for understanding many neurologic and psychiatric disorders. In this work, we developed a paramagnetic CEST-MRI method for dopamine detection using NaHoF₄@DBA nanoparticles. Our results showed that the dopamine in mouse brain can be selectively enriched in the surface of the nanoparticles and detected by CEST-MRI. Moreover, we found that the magnitude of ST% map reflecting dopamine levels in the brain of SZ mice was relatively higher than that of PD mice.

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