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Abstract #3843

Free-breathing abdominal CEST sequence using water presaturation and precise respiratory synchronization

Zhensen Chen1,2, Chuyu Liu3, Yishi Wang4, Weibo Chen5, Rui Guo6, He Wang1,7, and Xiaolei Song3
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China, 3Department of Biomedical Engineering, School of Medicine Tsinghua University, Beijing, China, 4Philips Healthcare, Beijing, China, 5Philips Healthcare, Shanghai, China, 6Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 7Human Phenome Institute, Fudan University, Shanghai, China


To date, chemical exchange saturation transfer (CEST) is rarely used in abdominal imaging of human body due to its high sensitivity to motion. In this study, we developed a free-breathing abdominal CEST sequence that uses a precise respiratory synchronization strategy and includes a water presaturation module. Preliminary in-vivo experiments showed that the proposed sequence outperformed non-triggered and breath-holding abdominal CEST in reducing the slice position inconsistency between the frequency offsets and motion-induced noise.

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