Abstract #3843

Free-breathing abdominal CEST sequence using water presaturation and precise respiratory synchronization

Zhensen Chen^1,2, Chuyu Liu³, Yishi Wang⁴, Weibo Chen⁵, Rui Guo⁶, He Wang^1,7, and Xiaolei Song³

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China, ³Department of Biomedical Engineering, School of Medicine Tsinghua University, Beijing, China, ⁴Philips Healthcare, Beijing, China, ⁵Philips Healthcare, Shanghai, China, ⁶Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, ⁷Human Phenome Institute, Fudan University, Shanghai, China

Synopsis

To date, chemical exchange saturation transfer (CEST) is rarely used in abdominal imaging of human body due to its high sensitivity to motion. In this study, we developed a free-breathing abdominal CEST sequence that uses a precise respiratory synchronization strategy and includes a water presaturation module. Preliminary in-vivo experiments showed that the proposed sequence outperformed non-triggered and breath-holding abdominal CEST in reducing the slice position inconsistency between the frequency offsets and motion-induced noise.

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