Deuterium MRS(I) has emerged as a novel metabolic imaging method. However, the deuterium labeled substrate such as [6,6’-2H2]glucose is expensive, which becomes one of the obstacles for the clinical translation of this technique. Recently, we developed a cost-effective synthesis route for a new deuterated compound [2,3,4,6,6’-2H5]glucose. The cost of [2,3,4,6,6’-2H5]glucose is significantly lower than the [6,6’-2H2]glucose. In this study, we demonstrate that this new compound can measure the glycolytic flux through a rat glioma model.
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