Deuterium metabolic imaging for glioma in rat model using [2,3,4,6,6’-2H5]glucose
Chao Zou1, Yingheng Ruan2, Feng Du1, Qikai Qin3, Qian Wan1, Jiawen Yuan1,4, Garth J. Thompson3, Xiaojun Yang2, Ye Li1, Xin Liu1, and Hairong Zheng1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Shenzhen Dingbang Bioscience Co., Ltd., Shenzhen, China, 3iHuman Institute, ShanghaiTech University, Shanghai, China, 4Southern University of Science and Technology, Shenzhen, China
Deuterium MRS(I) has emerged as a novel metabolic imaging method. However, the deuterium labeled substrate such as [6,6’-2H2]glucose is expensive, which becomes one of the obstacles for the clinical translation of this technique. Recently, we developed a cost-effective synthesis route for a new deuterated compound [2,3,4,6,6’-2H5]glucose. The cost of [2,3,4,6,6’-2H5]glucose is significantly lower than the [6,6’-2H2]glucose. In this study, we demonstrate that this new compound can measure the glycolytic flux through a rat glioma model.
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