Abstract #3841

Which CEST technique provides most insight into tumors – 3T APTw, 3T CEST-MRF or 7T multi-pool CEST?

Maria Sedykh¹, Moritz Fabian¹, Kai Herz^2,3, Or Perlman⁴, Christian Farrar⁴, Angelika Mennecke¹, Manuel Schmidt¹, Arnd Dörfler¹, and Moritz Zaiss^1,2

¹Neuroradiology, FAU Erlangen-Nuremberg, University Hospital, Erlangen, Germany, ²Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, ³Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, ⁴Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Synopsis

We report on only one glioblastoma patient, but who could be measured with several different CEST MRI methods: 3T APTw, 3T CEST fingerprinting, and 7T multi-pool CEST in order to reveal their relative performance and correlations. Coarse features can be observed in all methods, with MRF and 7T CEST being more versatile in non-active tumor parts. Isolation, separation and smarter combination of different CEST contrast is still needed to improve the diagnostic performance of CEST.

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