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Abstract #3841

Which CEST technique provides most insight into tumors – 3T APTw, 3T CEST-MRF or 7T multi-pool CEST?

Maria Sedykh1, Moritz Fabian1, Kai Herz2,3, Or Perlman4, Christian Farrar4, Angelika Mennecke1, Manuel Schmidt1, Arnd Dörfler1, and Moritz Zaiss1,2
1Neuroradiology, FAU Erlangen-Nuremberg, University Hospital, Erlangen, Germany, 2Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, 3Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, 4Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States


We report on only one glioblastoma patient, but who could be measured with several different CEST MRI methods: 3T APTw, 3T CEST fingerprinting, and 7T multi-pool CEST in order to reveal their relative performance and correlations. Coarse features can be observed in all methods, with MRF and 7T CEST being more versatile in non-active tumor parts. Isolation, separation and smarter combination of different CEST contrast is still needed to improve the diagnostic performance of CEST.

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