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Abstract #3854

Simultaneous macromolecular proton fraction and proton density fat fraction quantification using chemical shift-encoding based spin-lock MRI

Jian Hou1, Yurui Qian1, Baiyan Jiang1,2, Queenie Chan3, Zhigang Wu4, Vincent Wai-Sun Wong5, Dimitrios Karampinos6, Winnie Chiu-Wing Chu1, and Weitian Chen1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Illuminatio Medical Technology Limited, Hong Kong, Hong Kong, 3Philips Healthcare, Hong Kong, Hong Kong, 4Philips Healthcare, Shenzhen, China, 5Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 6Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany


Chronic liver disease is a major healthcare problem worldwide. Liver fibrosis and fat fraction are two main features of chronic liver diseases. Recent work reported that macromolecular proton fraction (MPF) mapping has potential for diagnosis of liver fibrosis. In this work, we reported a novel technique to quantify MPF and fat fraction of the liver simultaneously in a brief breath hold.

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