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Abstract #3855

Prediction of IDH, 1p/19q and TERTp Status: combination of APTw value of tumor solid and peritumoral area

Xinying Ren1, Diaohan Xiong1, Tiejun Gan1, Pengfei Wang1, Rui Wang1, Tao Wen1, Yujing Li1, Jing Zhang1, and Kai Ai2
1Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China


This study aims to analyze the metabolic information in both tumor solid and peritumoral area of gliomas to predict its genotype by using Amide Proton Transfer weighted (APTw) imaging. As a complementary method of pathological evaluation, APTw based MRI technique could provide a prediction of the gliomas genotype. Unlike other studies focus on tumor core region, our research investigated the APTmean value of tumor solid and the peritumoral area. Interestingly, the results showed that the AUC value of peritumoral area was higher than the tumor solid. The APTw images may serve as a potential marker for the genotyping of gliomas.

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