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Abstract #3856

A Nitroreductase Responsive Fluorescent/ 19F MRI Dual-Imaging Probe for Hypoxia Tumor Detection In Vivo

Long Xiao1, Yu Li1, Sha Li1, Yaping Yuan1, Lei Zhang1, Shizhen Chen1, and Xin Zhou1
1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences–Wuhan National Laboratory for Optoelectronics, Wuhan, China


We designed and synthesized a molecular probe-based on fluorescence imaging and 19F MRI bimodal imaging to identify overexpressed nitroreductase in hypoxic tumor. The two imaging modes complement each other in sensitivity and imaging depth, providing more abundant information. More importantly, the bimodal molecular probe is enriched in the tumor region depending on the passive targeting ability and has been well verified by fluorescence imaging and 19F MRI in the metastatic tumor model. And we successfully identified the cancerous left lung and healthy right lung in lung cancer model mouse.

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