We designed and synthesized a molecular probe-based on fluorescence imaging and 19F MRI bimodal imaging to identify overexpressed nitroreductase in hypoxic tumor. The two imaging modes complement each other in sensitivity and imaging depth, providing more abundant information. More importantly, the bimodal molecular probe is enriched in the tumor region depending on the passive targeting ability and has been well verified by fluorescence imaging and 19F MRI in the metastatic tumor model. And we successfully identified the cancerous left lung and healthy right lung in lung cancer model mouse.
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