In vivo measurement of human intraocular water movement using 1H-MRI with H217O saline eye drops
Moyoko Tomiyasu1, Yasuka Sahara1, Etsuko Mitsui1, Hiroki Tsuchiya2, Takamasa Maeda2, Nobuhiro Tomoyori3, Makoto Kawashima3, Tatsuya Higashi1, Atsushi Mizota3, Kohsuke Kudo4, and Takayuki Obata1
1Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology, Ciba, Japan, 2Department of Medical Technology, National Institutes for Quantum Science and Technology, Ciba, Japan, 3Department of ophthalmology, Teikyo University, Tokyo, Japan, 4Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan
We observed the movement of 17O-labelled water (H217O) in the eyes of three volunteers using dynamic T2W 1H-MRI (3T). After a drop of H217O saline in the right eye, the signal intensity in the right anterior chamber decreased, reaching a minimum at 7–9 min, and then gradually recovered to close to that seen before the eye drop, by about 40 min. Signal decrease and recovery was also observed in the posterior chamber, but not in the vitreous body. These results show that H217O drops flow smoothly into the human anterior chamber and flow out slowly.
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