We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally1. As demonstrated by our published work2, the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.
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