rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment
Ho Chi Joseph Lai1, Tian Yang2, Jianpan Huang1, Yang Liu1, Youngjin Lee2, and Wai Yan Kannie Chan1,3,4,5
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 2Department of Neuroscience, City University of Hong Kong, Hong Kong, Hong Kong, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, 5Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, Hong Kong
We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally1. As demonstrated by our published work2, the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.
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