Abstract #3858

rNOE imaging detects distinctive neuropathology in Intracerebral Hemorrhage (ICH) under deferoxamine treatment

Ho Chi Joseph Lai¹, Tian Yang², Jianpan Huang¹, Yang Liu¹, Youngjin Lee², and Wai Yan Kannie Chan^1,3,4,5

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ²Department of Neuroscience, City University of Hong Kong, Hong Kong, Hong Kong, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁵Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, Hong Kong

Synopsis

We have shown that CEST (APTw and rNOE) contrast demonstrated distinctive changes of ICH mouse brains longitudinally¹. As demonstrated by our published work², the rNOE changes could be primarily associated with changes in myelin. Here, we studied the APTw and rNOE contrast after ICH up to 14 days, and under DFX treatment. We observed regional changes of APTw and rNOE contrast in the core and peri-hematoma regions, especially the significant difference (P<0.05) on day 3 with and without DFX treatment. Our immunohistochemistry data indicated that rNOE contrast correlated with myelin, which supports that rNOE could detect myelin pathology during ICH.

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