Abstract #3859

Quantification of the impact of Gadolinium agent on amide-proton-transfer weighted MRI: an ex vivo and in vivo study

Qian Yang¹, Zhou Liu¹, Yin Wu², Long Qian³, and Dehong Luo¹

¹National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital，Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, ²Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ³MR Research, GE Healthcare, Beijing, China

Synopsis

The clinical value of Amide proton transfer (APT) imaging in brain tumors has been intensively studied and validated. However, whether and how much Gadolinium-based (Gd) agent in clinical dosage has impact on the APT-weighted signal in clinical scenarios remains controversial. Hence, this study designed an in vitro study using a phantom with a gradient dosage of Gd-based agent and then validated the result in 6 patients with brain tumors. The result revealed that APT effect was significantly influenced by Gd contrast agent both in the phantom in vitro study and in vivo study.

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