Abstract #3863

An Innovative MRI phantom Allowing Evaluation of the Influence of Fat Fraction on the Measurement of ADC under Different Glass Bead Densities

Jo-Hua Peng¹, Chun-Jung Juan^1,2,3, Yi-Jui Liu⁴, Ruey-Hwang Chou⁵, Hing-Chiu Chang⁶, Chang-Hsien Liou^2,7, Szu-Hsien Chou^1,2, Yen-Ting Wu^1,2, Bai-Wen Wu², and Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, ³Department of Radiology, School of Medicine, China Medical University, Taichung, Taiwan, ⁴Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ⁵Institute of Cancer Biology, China Medical University, Taichung, Taiwan, ⁶Department of Biomedical Engineering, Chinese University of Hong Kong, Sha Tin, Hong Kong, ⁷Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan

Synopsis

Although a single-function phantom for either ADC or fat content is popular, it is crucial to develop a multiple-function phantom to simulate the real situation of human tissue in vivo. The aim of our study was to design a novel phantom containing different fat fractions and cellularity to evaluate the effect of fat content on ADC measurement in vivo as in human tissue environment. In conclusion, the influence of fat contents and glass beads density on ADC values was examined in our dual-function phantom, which can be helpful to improve the accuracy of ADC quantification in clinical practice.

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