An Innovative MRI phantom Allowing Evaluation of the Influence of Fat Fraction on the Measurement of ADC under Different Glass Bead Densities
Jo-Hua Peng1, Chun-Jung Juan1,2,3, Yi-Jui Liu4, Ruey-Hwang Chou5, Hing-Chiu Chang6, Chang-Hsien Liou2,7, Szu-Hsien Chou1,2, Yen-Ting Wu1,2, Bai-Wen Wu2, and Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, 3Department of Radiology, School of Medicine, China Medical University, Taichung, Taiwan, 4Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 5Institute of Cancer Biology, China Medical University, Taichung, Taiwan, 6Department of Biomedical Engineering, Chinese University of Hong Kong, Sha Tin, Hong Kong, 7Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan
Although a single-function phantom for either ADC or fat content is popular, it is crucial to develop a multiple-function phantom to simulate the real situation of human tissue in vivo. The aim of our study was to design a novel phantom containing different fat fractions and cellularity to evaluate the effect of fat content on ADC measurement in vivo as in human tissue environment. In conclusion, the influence of fat contents and glass beads density on ADC values was examined in our dual-function phantom, which can be helpful to improve the accuracy of ADC quantification in clinical practice.
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