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Abstract #3873

Model-free mapping of neural activation in brain white matter based on local fiber architecture

Yu Zhao1, Yurui Gao1, Zhongliang Zu1, Muwei Li1, Kurt Schilling1, Adam W. Anderson1, Zhaohua Ding1, and John C. Gore 1
1Vanderbilt University Medical Center, Nashville, TN, United States


We propose a model-free method to detect BOLD signal changes in brain white matter (WM) without an assumption of a hemodynamic response function or a linear shift-invariant response as assumed in conventional general linear models. Instead, neural activations are measured by the synchrony of BOLD signals under constraints of the anisotropic architecture of WM fibers. A 60 subject sub-group sourced from the Human Connectome Project database was used to validate the proposed method at a group level. Our results demonstrate that the proposed method can probe neural activations in WM with high sensitivities and high specificities.

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