We propose a model-free method to detect BOLD signal changes in brain white matter (WM) without an assumption of a hemodynamic response function or a linear shift-invariant response as assumed in conventional general linear models. Instead, neural activations are measured by the synchrony of BOLD signals under constraints of the anisotropic architecture of WM fibers. A 60 subject sub-group sourced from the Human Connectome Project database was used to validate the proposed method at a group level. Our results demonstrate that the proposed method can probe neural activations in WM with high sensitivities and high specificities.
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