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Abstract #3874

Local BOLD correlations in white matter measured under constraints of fiber orientation

Yurui Gao1, Yu Zhao2, Kurt G Schilling2, Muwei Li2, Adam W Anderson1, Zhaohua Ding1, and John C Gore2
1VANDERBILT UNIVERSITY, Nashville, TN, United States, 2Vanderbilt University Medical Center, Nashville, TN, United States


Correlations between BOLD signals from adjacent voxels in white matter (WM) are anisotropic and appear similar to metrics that describe functional connectivity in gray matter. We propose a method to measure the fiber-oriented correlation (FOC) between BOLD signals in WM. This method was implemented on both resting state and motor task fMRI data across 64 HCP subjects. The FOC map revealed WM areas apparently engaged in default mode network and visual function in both rest and task conditions. The motor task map also delineates the corticospinal tract. The proposed metric FOC may be valuable for investigating functional WM pathways.

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