Abstract #3886

Brain cortical changes are related to SARS-CoV-2 inflammatory biomarkers in hospitalized patients with neurological manifestations

Gretel Sanabria-Diaz¹, Manina Maja Etter ^2,3, Lester Melie-Garcia^1,4, Johanna Maria Lieb⁵, Marios-Nikos Psychogios⁵, Gregor Hutter^2,3, and Cristina Granziera^1,4

¹Department of Medicine and Biomedical Engineering, Translational Imaging in Neurology (ThINK), University Hospital Basel and University of Basel, Basel, Switzerland, ²Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland, ³Division of Neurosurgery, University Hospital Basel, Basel, Switzerland, ⁴Neurologic Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, ⁵Department of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland

Synopsis

A quantitative imaging study is critical to detect cortical brain macrostructural alterations associated with an inflammatory response in hospitalized SARS-CoV-2 patients. Using automated processing of the 3D high-resolution T1-weighted anatomical images, we found a decrease of cortical gray matter volume and thickness, but not in the surface area related to increased levels in CSF protein, CSF blood/albumin ratio, and CSF EN-RAGE. The anatomical localization of these regions may be the in vivo hallmarks of the virus effect on the brain cortex due to a hyperinflammatory response and associated with neurological deficits presented in acute and post-Covid phases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.