Mild traumatic brain injury (mTBI) accounts for the majority of head injuries and is often associated with physical, cognitive, and effective deficits. We used fixel-based analysis (FBA) to investigate the white matter (WM) structural alterations in acute mTBI patients. Three fixel-based metrics were used: fibre density (FD), fibre-bundle cross-section area (FC) and a combination of FD and FC (FDC). We found out that mTBI patients demonstrated reduced FC and FDC in multiple WM tracts and it may suggest that FBA can be used to detect subtle WM changes following mild injuries.
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