Abstract #3887

A fixel-based analysis of white matter alterations in patients with acute mild traumatic brain injury

Li Jiang^1,2, Jiachen Zhuo^1,2, Steven Roys^1,2, Rosy Linda Njonkou Tchoquessi^1,2, and Rao Gullapalli^1,2

¹Center for Advanced Imaging Research, University of Maryland Baltimore, Baltimore, MD, United States, ²Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States

Synopsis

Mild traumatic brain injury (mTBI) accounts for the majority of head injuries and is often associated with physical, cognitive, and effective deficits. We used fixel-based analysis (FBA) to investigate the white matter (WM) structural alterations in acute mTBI patients. Three fixel-based metrics were used: fibre density (FD), fibre-bundle cross-section area (FC) and a combination of FD and FC (FDC). We found out that mTBI patients demonstrated reduced FC and FDC in multiple WM tracts and it may suggest that FBA can be used to detect subtle WM changes following mild injuries.

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