Meeting Banner
Abstract #3887

A fixel-based analysis of white matter alterations in patients with acute mild traumatic brain injury

Li Jiang1,2, Jiachen Zhuo1,2, Steven Roys1,2, Rosy Linda Njonkou Tchoquessi1,2, and Rao Gullapalli1,2
1Center for Advanced Imaging Research, University of Maryland Baltimore, Baltimore, MD, United States, 2Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States


Mild traumatic brain injury (mTBI) accounts for the majority of head injuries and is often associated with physical, cognitive, and effective deficits. We used fixel-based analysis (FBA) to investigate the white matter (WM) structural alterations in acute mTBI patients. Three fixel-based metrics were used: fibre density (FD), fibre-bundle cross-section area (FC) and a combination of FD and FC (FDC). We found out that mTBI patients demonstrated reduced FC and FDC in multiple WM tracts and it may suggest that FBA can be used to detect subtle WM changes following mild injuries.

This abstract and the presentation materials are available to members only; a login is required.

Join Here