Abstract #3888
Genetic susceptibility to myelin and axonal injury as measured by myelin water imaging and multi-shell diffusion in multiple sclerosis
Reza Rahmanzadeh1,2, Stefan Herms3, Bettina Burger3, Po-Jui Lu1,2, Muhamed Barakovic1,2, Matthias Weigel1,2, Thanh D. Nguyen4, Yi Wang4, Francesco La Rosa 5,6, Meritxell Bach Cuadra 5,6, Ernst-Wilhelm Radue1, Jens Kuhle2, Ludwig Kappos2, Sven Cichon3,7, and Cristina Granziera1,2
1Translational Imaging in Neurology Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 2Neurologic Clinic and Policlinic, Switzerland, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 3Human Genomics Research Group, Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland, 4Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 5Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 6Radiology Department, Center for Biomedical Imaging (CIBM), Lausanne University and University Hospital, Lausanne, Switzerland, 7Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
Synopsis
Despite several large-scale genome-wide association studies (GWAS) have been performed in MS, to date no study explored the relationship between genetic risk factors for MS and the extent of myelin and axon damage in the brain of MS patients, as measured by advanced MRI techniques. Our results identify novel genetic loci that might be associated with myelin and axonal pathology in MS Patients.
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