Meeting Banner
Abstract #3889

High-spatial resolution mapping of microvascular permeability-surface area product using dual temporal resolution DCE-MRI techniques

Ka-Loh Li1, Daniel Lewis2, Xiaoping Zhu1, Alan Jackson1, and Timothy Cootes1
1Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust,, Manchester, United Kingdom


A limitation of the extended Tofts model (ETM) is that estimates of Ktrans, transfer constant, reflect both capillary plasma flow (Fp) and the capillary permeability-surface area product (PS). Other DCE-MRI models can separate out these physiological effects, but such models mandate high-temporal resolution data, compromising spatial resolution and volume coverage. In this in vivo brain tumor study, we demonstrate that incorporating the ETM and an early-timepoints absolute CBF (ET-CBF) method with a dual-temporal resolution, DCE-MRI approach, termed LEGATOS, permits generation of high-spatial resolution maps of Ktrans, Fp and PS, allowing high-spatial resolution interrogation of flow and permeability effects.

This abstract and the presentation materials are available to members only; a login is required.

Join Here