Longitudinal Assessment of Tumor Perfusion in Glioblastoma using Arterial Spin Labeled MRI: Preliminary Findings
Yiming Wang1, Marco C. Pinho1,2, Limin Zhou1, Michael N. Youssef3,4, Joseph A. Maldjian1,2, and Ananth J. Madhuranthakam1,2
1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Neurology, UT Southwestern Medical Center, Dallas, TX, United States, 4Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States
In Glioblastoma (GBM) patients undergoing chemoradiation, decreased tumor perfusion can be observed in treatment-responding patients and earlier than changes in tumor volume measured by conventional MRI. Such perfusion changes can be measured by non-contrast Arterial Spin Labeled (ASL) MRI, which is particularly suitable for longitudinal assessment of tumor perfusion. In this study, we performed longitudinal perfusion measurements using ASL MRI in patients with glioblastoma undergoing chemoradiation. Progressive perfusion reduction was observed in a representative patient's enhancing tumor ROIs along with increased ADC values, indicating reduced tumor cellularity, which likely results from treatment responses.
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