In Glioblastoma (GBM) patients undergoing chemoradiation, decreased tumor perfusion can be observed in treatment-responding patients and earlier than changes in tumor volume measured by conventional MRI. Such perfusion changes can be measured by non-contrast Arterial Spin Labeled (ASL) MRI, which is particularly suitable for longitudinal assessment of tumor perfusion. In this study, we performed longitudinal perfusion measurements using ASL MRI in patients with glioblastoma undergoing chemoradiation. Progressive perfusion reduction was observed in a representative patient's enhancing tumor ROIs along with increased ADC values, indicating reduced tumor cellularity, which likely results from treatment responses.
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