Abstract #3892
Inter-observer variability in MR-based target volume delineation of uveal melanoma
L. Klaassen1,2,3, M.G. Jaarsma-Coes1,2, B.M. Verbist2, T.H.K. Vu1, Y.L.B. Klaver3,4, M.F. Rodrigues3,4, T.A. Ferreira2, C. Nabarro2, G.P.M. Luyten1, C.R.N. Rasch3,4, M. van Herk5, and J.W.M. Beenakker1,2,3
1Ophthalmology, Leiden University Medical Center, Leiden, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands, 4Radiation Oncology, HollandPTC, Delft, Netherlands, 5Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom
Synopsis
The aim of this study was to assess the inter-observer variation in gross target volume (GTV) delineation of uveal melanoma on MRI. Six observers delineated the GTV in ten different patients on T2-weighted and contrast-enhanced T1-weighted scans. The average interobserver variation appeared slightly higher on T1gd (0.41 mm) compared to T2 (0.35 mm), although the difference was not significant (p=0.12). We recommend to delineate based on the T1gd-weighted scans, as parts of the tumour might be missed on T2.
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