Abstract #3892

Inter-observer variability in MR-based target volume delineation of uveal melanoma

L. Klaassen^1,2,3, M.G. Jaarsma-Coes^1,2, B.M. Verbist², T.H.K. Vu¹, Y.L.B. Klaver^3,4, M.F. Rodrigues^3,4, T.A. Ferreira², C. Nabarro², G.P.M. Luyten¹, C.R.N. Rasch^3,4, M. van Herk⁵, and J.W.M. Beenakker^1,2,3

¹Ophthalmology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands, ⁴Radiation Oncology, HollandPTC, Delft, Netherlands, ⁵Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom

Synopsis

The aim of this study was to assess the inter-observer variation in gross target volume (GTV) delineation of uveal melanoma on MRI. Six observers delineated the GTV in ten different patients on T2-weighted and contrast-enhanced T1-weighted scans. The average interobserver variation appeared slightly higher on T1gd (0.41 mm) compared to T2 (0.35 mm), although the difference was not significant (p=0.12). We recommend to delineate based on the T1gd-weighted scans, as parts of the tumour might be missed on T2.

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