Neural excitability through BOLD variability in the preterm brain: A longitudinal resting-state fMRI study
Serafeim Loukas1,2, Joana Sa de Almeida1, Djalel Eddine Meskaldji1,3, Dimitri Van De Ville2,4, and Petra Susan Hüppi1
1Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 2Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Institute of Mathematics, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland
Resting-state functional connectivity based on simultaneous BOLD oscillations has been described both in preterm infants and fullterm newborns. During this period of rapid cerebral cortex development, different brain activity patterns (networks) have been previously described. Regional changes in spontaneous BOLD signal variability on the other hand reflect local intravoxel BOLD changes related to neural excitability/flexibility. In the present study, we aimed to explore the longitudinal evolution of the BOLD variability between birth and term-equivalent-age (TEA), a period of rapid brain development, in preterm-born infants. Our findings suggest increased variability at TEA as compared to birth in important primary cortices.
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