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Abstract #3898

Inter-site reliability of diffusion microstructure measurements: A 3-tissue constrained spherical deconvolution study

Richard L Huang1, Benjamin T Newman1, and T Jason Druzgal1
1University of Virginia School of Medicine, Charlottesville, VA, United States


As large multi-site neuroimaging and diffusion MRI (dMRI) microstructure studies become more common, it is necessary to understand factors affecting reliability of outcome measurements collected across different sites. In this study, we analyze dMRI collected from 3 subjects traveling to 10 different sites with identical MRI scanners, sequence protocols, and software. We perform a detailed microstructural analysis in 212 grey matter and white matter brain regions and find that measurements are generally reliable across sites. However, there remains variation in specific locations that may suggest caution when interpreting small effects in small or hard to measure brain regions.

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