Subcutaneous adipose tissue water fraction increases with weight loss in persons with obesity
Jessie Han1, Mingming Wu1, Selina Rupp1, Daniela Junker1, Anna Reik2, Meike Wiechert2, Hans Hauner2,3, Marcus R. Makowski1, Christina Holzapfel2, Stefan Ruschke1, and Dimitrios C. Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany, 3Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany
Subcutaneous adipose tissue (SAT) dysfunction is key in defining high-risk individuals in obesity. A change in adipose tissue water fraction with weight loss may reflect improvement in blood flow or changes in microstructure of adipose tissue. Single-voxel STEAM Magnetic Resonance Spectroscopy (MRS) and chemical shift encoded-based water-fat separation are non-invasive methods to assess the water fraction and proton density fat fraction (PDFF) of adipose tissue. The present work aims to investigate the feasibility of MRS and water-fat separation to quantify PDFF and evaluate the changes in SAT water fraction in persons with obesity undergoing an 8-week weight loss intervention.
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