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Abstract #3896

Dynamic contrast-enhanced MRI reveals decreased pulmonary perfusion in COVID-19 Survivors

Iris Y. Zhou1,2, Michael C. Magaletta1, Molly Mascia2,3, George A. Alba2,3, Peter Caravan1,2, and Sydney B. Montesi2,3
1Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States


Coronavirus disease 2019 (COVID-19) has been shown to cause pathologic aberrancies in the vascular endothelium. We performed dynamic contrast-enhanced (DCE) MRI on participants with prior COVID-19 to assess differences in pulmonary microvascular perfusion compared with healthy volunteers. Significantly reduced peak enhancement, slower rate of contrast arrival, and longer mean transit time were found in COVID-19 survivors compared to healthy controls, indicating reduced microvascular perfusion months after initial SARS-CoV-2 infection. The DCE MRI readouts can potentially be used as quantitative imaging biomarkers of pulmonary vascular change and may provide important insights into COVID-19 microvascular pathobiology and outcome.

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