The relatively poor temporal signal-to-noise ratio (tSNR) in resting-state fMRI (rsfMRI) serves to be a pressing area of improvement. NOise Reduction with Distributed Corrected (NORDIC) PCA can effectively increase tSNR. However, it has yet to be examined in rodent rsfMRI studies. Here, we applied NORDIC-correction to mouse rsfMRI, and evaluated the tSNR and functional connectivity against standard preprocessing data. NORDIC was able to significantly increase tSNR and reduce functional connectivity variability. NORDIC can also denoise rsfMRI signals at higher frequencies. Taken together, NORDIC can potentially become an important preprocessing step in future rodent rsfMRI studies.
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