Abstract #3929

Vascular Mapping of the Human Hippocampus Using USPIO

Sagar Buch¹, Yongsheng Chen², Pavan Jella³, Yulin Ge⁴, and Ewart Mark Haacke¹

¹Radiology, Wayne State University, Detroit, MI, United States, ²Neurology, Wayne State University, Detroit, MI, United States, ³Wayne State University, Detroit, MI, United States, ⁴Radiology, New York University School of Medicine, New York, NY, United States

Synopsis

In this work, we introduce the use of Ferumoxytol, an ultra-small superparamagnetic iron oxides (USPIO) agent, to increase the susceptibility in the veins and arteries to map the hippocampal microvasculature and to evaluate the fractional vascular density (FVD) in each of its subfields. We found that the hippocampal fissure, along with the fimbria, granular cell layer of the dentate gyrus and cornu ammonis layers (except for CA1), showed higher microvascular FVD than other parts of the hippocampus.

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