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Abstract #3930

Brain Tumour Studies using Low-Dose Gadolinium-Based Contrast Agent Dynamic Contrast Enhancement MRI

Xiaoping Zhu1, Daniel Lewis2, Ka-Loh Li1, and Alan Jackson1
1DIIDS, University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom


Using one-fifth of standard GBCA dose, high spatial resolution (LDHS) whole brain pharmacokinetic maps was calculated and compared with those from dual temporal resolution (DTR) DCE, which combines high temporal resolution (LDHT) and full dose spatial resolution DCE. Results from Monte Carlo simulation suggested the measurement uncertainty and bias reduced to negligible whilst CNR of tumour concentration curves is greater than 3.1. The in-vivo LDHS maps have compatible accuracy with those from HT DCE, moreover revealing tumor heterogeneity to the quality DTR have achieved. Largely reduced dose enabled safer exams for patients undergoing repeated administration of GBCA.

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