Using one-fifth of standard GBCA dose, high spatial resolution (LDHS) whole brain pharmacokinetic maps was calculated and compared with those from dual temporal resolution (DTR) DCE, which combines high temporal resolution (LDHT) and full dose spatial resolution DCE. Results from Monte Carlo simulation suggested the measurement uncertainty and bias reduced to negligible whilst CNR of tumour concentration curves is greater than 3.1. The in-vivo LDHS maps have compatible accuracy with those from HT DCE, moreover revealing tumor heterogeneity to the quality DTR have achieved. Largely reduced dose enabled safer exams for patients undergoing repeated administration of GBCA.
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