Abstract #3935

Detection of IDH mutation in brain tumors using RAFF, continues wave T1rho, adiabatic T1rho, adiabatic T2rho and high b-value DWI

Harri Merisaari^1,2, Aida Steiner¹, Marko Pesola ¹, Maria Gardberg ³, Janek Frantzén ⁴, Pekka Jokinen ⁴, Hannu Aronen ¹, Timo Liimatainen ⁵, Heikki Minn ⁶, and Ivan Jambor^1,7

¹Department of Radiology, University of Turku, Turku, Finland, ²Turku Brain and Mind Center, University of Turku, Turku, Finland, ³Department of Pathology, Turku University Hospital, Turku, Finland, ⁴Department of Neurosurgery, Turku University Hospital, Turku, Finland, ⁵Department of Radiology, University of Oulu, Oulu, Finland, ⁶Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland, ⁷Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

Synopsis

We evaluated the potential of Relaxation Along a Fictitious Field in second rotating frame (TRAFF2), continues wave T1rho (T1ρcw), adiabatic T1rho (T1ρadiab), adiabatic T2rho (T2ρadiab), DWI and anatomical MRI to differentiate isohydrogenase dehydrogenase (IDH) status between IDH wild type and IDH mutation in 22 patients with glioma. In voxel level analysis, DWI derived parameters using bi-exponential model (0-4000 s/mm2) provided improved performance in classification of IDH status of brain gliomas compared with TRAFF2, T1ρcw, T1ρadiab, T2ρadiab and anatomical MRI.

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