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Abstract #3937

Quantitative MRI biomarkers for cortical pathology in multiple sclerosis at 7 Tesla

Sina Straub1, Edris El-Sanosy2, Julian Emmerich1, Frederik L. Sandig2, Mark E. Ladd1,3,4, and Heinz-Peter Schlemmer2
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 4Faculty of Medicine, Heidelberg University, Heidelberg, Germany


Although substantial cortical gray matter tissue damage has been revealed by advanced MRI methods and in histopathology studies, clinical assessment of MS still mainly focuses on white matter lesions. When cortical pathology is evaluated, predominantly structural markers are used. In this ultra-high field study, data for $$$T_1$$$, $$$T_2$$$, $$$R_2^*$$$, $$$T_1w-T_2w$$$-ratio, and susceptibility mapping were acquired in 21 patients and 17 healthy controls. $$$T_1$$$–weighted data were post-processed to obtain cortical gray matter and deep gray matter segmentations. Statistically significant differences were found in 31 out of 34 investigated cortical and in three out of four deep gray matter regions (p<0.05).

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