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Abstract #3939

Spin Echo-Echo Planar Imaging Sequence Validation for MR Elastography of Intervertebral Discs

Megan Co1, Huiming Dong2, Daniel J. Boulter2, Xuan V. Nguyen2, Safdar N. Khan2, Brian Raterman2, Brett Klamer3, Arunark Kolipaka1,2, and Benjamin A. Walter1,2,4
1Biomedical Engineering, The Ohio State University, Columbus, OH, United States, 2Radiology, The Ohio State University, Columbus, OH, United States, 3Center for Biostatistics, The Ohio State University, Columbus, OH, United States, 4Spine Research Institute, The Ohio State University, Columbus, OH, United States

Synopsis

Magnetic resonance elastography (MRE) is an imaging technique that can non-invasively assess shear properties of intervertebral discs (IVD), a potential biomarker for disease. This study validated the use of a spin echo-echo planar imaging (SE-EPI) sequence for MRE of the IVD compared against the standard gradient recalled echo (GRE) sequence. Volunteers were scanned with the GRE and two variants of the SE-EPI sequence: SE-EPI with breath holds (SE-EPI-BH) and SE-EPI with free breathing (SE-EPI-FB). SE-EPI-based MRE-derived stiffnesses are highly reproducible and repeatable and correlate with current standard GRE MRE-derived stiffness estimates while reducing scan times and potentially improving patient compliance.

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