Rapid T2’ quantification by 10-echo GESE-EPIK sequence with application to oxygen extraction fraction imaging
Fabian Küppers1,2, Seong Dae Yun1, and N. Jon Shah1,3,4,5
1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, 2RWTH Aachen University, Aachen, Germany, 3Institute of Neuroscience and Medicine - 11, Forschungszentrum Jülich, Jülich, Germany, 4JARA-BRAIN - Translational Medicine, Aachen, Germany, 5Department of Neurology, RWTH Aachen University, Aachen, Germany
Owing to the advantages afforded by the simultaneous acquisition of T2/T2* in several practical applications, interest in this area remains high. In light of this, here we present an improved NLSQ fitting algorithm and a more detailed validation based of our previously introduced 10-echo GESE-EPIK sequence. The validation consists of two new phantoms, including a spectroscopic comparison to reference methods, and data from five in vivo subjects at 3T. In addition, GESE-EPIK is applied to OEF quantification during a breath-hold experiment to demonstrate its sensitivity to challenge-related changes.
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