Owing to the advantages afforded by the simultaneous acquisition of T2/T2* in several practical applications, interest in this area remains high. In light of this, here we present an improved NLSQ fitting algorithm and a more detailed validation based of our previously introduced 10-echo GESE-EPIK sequence. The validation consists of two new phantoms, including a spectroscopic comparison to reference methods, and data from five in vivo subjects at 3T. In addition, GESE-EPIK is applied to OEF quantification during a breath-hold experiment to demonstrate its sensitivity to challenge-related changes.
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