We propose a new calibrated fMRI approach for non-invasive measurement of the cerebral metabolic rate of oxygen of oxygen consumption and the deoxyhaemoglobin weighted blood volume. The method exploits the differential dependence of the gradient and spin echo BOLD signals on OEF. Unlike conventional calibrated approaches, we show that gradient-spin echo calibrated fMRI requires only a single respiratory modulation to determine OEF. The method is applied in-vivo using a repeated breath-holding protocol, and initial results show agreement with global measurements of oxygen saturation.
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