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Abstract #3945

Combining gradient and spin echo calibrated fMRI for mapping brain oxygen extraction fraction

Michael Germuska1,2, Antonio Maria Chiarelli 3,4, Hannah Chandler1, Ian Driver1, and Richard Wise3,4
1School of Psychology, Cardiff University, Cardiff, United Kingdom, 2School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, 3Department of Neuroscience, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy, 4Institute for Advanced Biomedical Technologies, University “G. d'Annunzio” of Chieti-Pescara, Chieti, Italy

Synopsis

We propose a new calibrated fMRI approach for non-invasive measurement of the cerebral metabolic rate of oxygen of oxygen consumption and the deoxyhaemoglobin weighted blood volume. The method exploits the differential dependence of the gradient and spin echo BOLD signals on OEF. Unlike conventional calibrated approaches, we show that gradient-spin echo calibrated fMRI requires only a single respiratory modulation to determine OEF. The method is applied in-vivo using a repeated breath-holding protocol, and initial results show agreement with global measurements of oxygen saturation.

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