White matter inflammation and its relation to myelin content in vivo in patients at different stages of multiple sclerosis.
Valeria Barletta1, Elena Herranz1, Constantina Andrada Treaba1, Ambica Mehndiratta2, Russell Ouellette3, Tobias Granberg4, Eric Klawiter5, Carolina Ionete6, Jacob Sloane7, and Caterina Mainero1
1Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 3Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden, 4Karolinska University Hospital, Department of Neuroradiology, Stockholm, Sweden, 5Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 6Umass Memorial Medical Center, Worcester, MA, United States, 7Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States
We combined 11C-PBR28 magnetic resonance-positron emission tomography, marking activated microglia, with synthetic MRI to measure myelin content, on a group of 33 patients affected by multiple sclerosis, to quantify neuroinflammation in the brain white matter and assess its relation to myelin content and disease burden. Microglia activation was higher in the white matter of multiple sclerosis patients compared to 16 healthy volunteers. Microglia activation within perilesional WM correlated the most with worse disease outcomes. Peripherally active lesions were related to higher disability and progressive disease. Perilesional myelin content was lower for higher inflammation and correlated with disease burden.
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