In multiple sclerosis, experimental and histopathological studies point to fibrinogen as a link between a damaged brain blood barrier and the initiation of the inflammatory demyelination and neurodegeneration in both cortex and white matter. Nevertheless, although the widespread accumulation of fibrinogen as fibrin deposits within multiple sclerosis lesions is well documented on postmortem brain tissue, in vivo evidence is still lacking. Using a novel fibrin-specific positron emission tomography probe, 64Cu-FBP8, we were able to demonstrate in vivo fibrin deposition not only in active white matter multiple sclerosis lesions but also in the cortex of a few multiple sclerosis patients.
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