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Abstract #3958

Quantitative T2* and T1 mapping of post-mortem MS tissue at 7T for discrimination of normal-appearing and dirty-appearing white matter pathology

Risavarshni Thevakumaran 1,2, Adam Groh 3,4, Jo Anne Stratton3,4, and David Rudko 1,2,3
1Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, 2McConnell Brain Imaging Centre, Montreal, QC, Canada, 3Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 4Montreal Neurological Institute-Hospital, Montreal, QC, Canada

Synopsis

Quantitative T2* and T1 relaxometry metrics calculated at 7T have high sensitivity to myelin and can be jointly used to identify dirty-appearing white matter (DAWM) and normal-appearing white matter (NAWM) pathology in post-mortem, multiple sclerosis (MS) brain tissue. Relaxometry mapping was performed on fixed, cerebral brain samples from MS patients and healthy donors. T2* and T1 distributions in WM from MS tissue exhibited bimodality and were shifted to higher relaxation time values compared to healthy tissue. Using k-means clustering applied to 2D T2* and T1 MS tissue data, regions of DAWM were detected in periventricular WM for MS tissue samples.

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