Characterization of cerebral vascular compliance (VC) could offer more insights into the vascular contribution to cognitive impairment. Cerebral VC can be measured using ASL methods but with a long scan time. A recent study introduced a fast MRI technique to assess global cerebral VC by measuring carotid pulse wave velocity (cPWV) using a single-slice oblique-sagittal PC-MRI. In this study, the robustness of cPWV measurement to the variations of ROI selection has been demonstrated. The results from a pilot study on an aged cohort suggests elevated cPWV is associated with cognitive decline and could be a potential marker for cognitive impairment.