Abstract #3959

Evaluation of the robustness of carotid pulse wave velocity measurement using a single-slice oblique-sagittal phase-contrast MRI

Jianing Tang¹, Soroush Heidari Pahlavian¹, Helena Chui², and Lirong Yan^1,2

¹USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

Characterization of cerebral vascular compliance (VC) could offer more insights into the vascular contribution to cognitive impairment. Cerebral VC can be measured using ASL methods but with a long scan time. A recent study introduced a fast MRI technique to assess global cerebral VC by measuring carotid pulse wave velocity (cPWV) using a single-slice oblique-sagittal PC-MRI. In this study, the robustness of cPWV measurement to the variations of ROI selection has been demonstrated. The results from a pilot study on an aged cohort suggests elevated cPWV is associated with cognitive decline and could be a potential marker for cognitive impairment.

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