Differential Effect of Dementia Etiology on Cortical Stiffness as Assessed by MR Elastography
KowsalyaDevi Pavuluri1, Jonathan M. Scott2, John Huston III1, Richard L. Ehman1, Armando Manduca1,3, Clifford R. Jack1, Rodolfo Savica4, Bradley F Boeve5, Kejal Kantarci1, Ronald C. Petersen4, and Matthew C. Murphy1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Mayo Clinic Medical Scientist Training Program, Mayo Clinic, Rochester, MN, United States, 3Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States, 4Department of Neurology, Mayo Clinic, Rochester, MN, United States, 5Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States
Dementia is a progressive neurodegenerative syndrome characterized by impairment in memory and activities of daily living, altered behavior, personality, and other cognitive dysfunctions. Around 50 million people have dementia worldwide, and there are nearly 10 million new cases every year. MR elastography is a non-invasive imaging technique to measure the mechanical properties of tissues and has demonstrated sensitivity to neurodegenerative processes. In this study we utilized two neural network inversions to investigate the viscoelastic property changes in cortical regions with both tissue- and environment-weighting in various etiologies of dementia including Alzheimer’s, frontotemporal dementia, and dementia with Lewy bodies.
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